From The Feinstein Institutes for Medical Research 21/08/23

In an unprecedented clinical trial, researchers from Northwell Health’s The Feinstein Institutes for Medical Research have implanted microchips into the brain of a man with paralysis.

They’ve also developed artificial intelligence (AI) algorithms to reconnect his brain to his body and spinal cord.

This innovative double neural bypass creates an electronic bridge that restores communication between his paralyzed body and brain, resulting in movement and sensations in his hand.

Feinstein Institutes’ bioelectronic medicine researchers hold a 3-D model of the skull and brain of a man with quadriplegia just prior to a historic surgery at Northwell Health’s North Shore University Hospital. Doctors and scientists used the model to help identify where to place five tiny computer chips in the brain to help restore not only lasting movement in the paralyzed man’s arm and hand, but also the sense of touch. CREDIT: The Feinstein Institutes for Medical Research

This breakthrough was achieved four months after a 15-hour open-brain surgery at North Shore University Hospital.

Chad Bouton, a professor at the Institute of Bioelectronic Medicine at Feinstein Institutes, highlighted the significance of this achievement.

He stated that this is the first instance where the brain, body, and spinal cord have been electronically linked to restore lasting movement and sensation in a paralyzed individual.

The trial participant’s arm and wrist movements improved outside the laboratory due to this technology.

Keith Thomas, a man who was paralyzed from the chest down after a diving accident, became the first human to benefit from this technology.

Keith Thomas, who lives with paralysis, poses with the research team at Northwell Health’s Feinstein Institutes for Medical Research that worked with him for months to restore lasting movement and feeling in his arm and hand. The first-of-its-kind ‘double neural bypass’ system uses brain implants and artificial intelligence to allow signals to and from Thomas’ brain to bypass the site of his injury. CREDIT: The Feinstein Institutes for Medical Research

Following a 15-hour surgery and months of research, his brain was mapped to identify the areas responsible for arm movement and sensation in his hand.

Surgeons then implanted chips in these specific brain regions.

Through thought-driven therapy and AI algorithms, Mr. Thomas can now control his movements and feel sensations in his hand.

Over a hundred million people globally suffer from movement impairment or paralysis.

This trial aims to restore movement and sense of touch beyond the laboratory.

By connecting brain implants to a computer, Mr. Thomas’s intentions translate into actions through stimulation of his spinal cord and muscles.

Using brain implants, AI, and novel stimulation technology, researchers complete the first ‘double neural bypass’. CREDIT: The Feinstein Institutes for Medical Research at Northwell Health

This innovative approach has the potential to promote natural recovery as well.

Mr. Thomas’s arm strength has significantly improved since the study began, and he’s beginning to feel sensations in his forearm and wrist, even without the system on.

Unlike previous single neural bypass approaches, this technology offers movement and feeling restoration while promoting plasticity for long-lasting natural recovery.

The hope is that the brain, body, and spinal cord will reestablish communication, forging new pathways similar to how organs regenerate.

The Feinstein Institutes for Medical Research are pioneering bioelectronic medicine, blending molecular medicine, neuroscience, and biomedical engineering.

Their innovative approach offers new possibilities for those with paralysis and loss of sensation, potentially changing the landscape of medical treatment.

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The Feinstein Institutes for Medical Research

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